Famotidine is histamine H2-receptor antagonist widely used in the treatment of gastric ulcers. Famotidine is having a short biological half-life of 2.5-3.5 hrs. To overcome the multiple doses at short intervals of time due to short biological half-life and poor bioavailability of famotidine, it was formulated into gastroretentive floating tablets, employing a new floating polymer tamarind kernel gum and known polymers HPMC-K4M and HPMCK15M. Eventhough there are several floating polymers, there is a continuous need to develop new floating polymer for better buoyancy and controlled release of drug. Isolated tamarind kernel gum is off white, free flowing and amorphous in nature which is supported by XRD and micromeritic studies. The formulation employing tamarind kernel gum showed slow release i.e spread over 12hrs and followed first order kinetics with non fickian diffusion of drug release. Isolated tamarind gum is comparable to HPMC K-15M in floating and a drug release characteristics and it was found to be better than HPMC K4M. So it was concluded that tamarind kernel gum could be used as floating and controlled release polymer in the formulation of gastroretentive formulations.
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